Diapetes
Diabetekseltä suojaavia itsenäisiä
ja toisistaan riippumattomia vaikutuksia saattaa olla pellavansiementen
sisältämällä ravintokuidulla (Anderson 1999), lignaanilla (Prasad 2000,
Prasad ym. 2000, Prasad 2001) ja alfalinoleenihapolla (Caughey ym.
1996, Prasad ym. 2000).
Diabetekseen liittyviä epidemiologisia
tutkimuksia kokoavassa katsauksessa todetaan, että monityydyttymättömät
rasvahapot, ja mahdollisesti erityisesti pitkäketjuiset omega-3-hapot,
saattavat olla hyödyllisiä diabeteksen ehkäisyssä (Hu ym. 2001).
Eläinkokeiden perusteella ruokavalion rasvahappokoostumuksella saattaa
olla merkittäviä vaikutuksia elimistön sokeriaineenvaihduntaan
(Storlien ym. 1987, Storlien ym. 1991, Chicco ym. 1996, Luo ym. 1996,
Nobukata ym. 2000). Kokeellisesti saatu näyttö on terveiden ihmisen
osalta vielä kovin vähäistä ja puutteellista, mutta
omega-3-rasvahapoilla on saatu lisätyksi insuliiniherkkyyttä
diabeetikoilla (Popp-Snijders ym. 1987) sekä kudosten glukoosinsietoa
resistenssioireisilla (Fasching ym. 1991).
Viitteet
Anderson JW. 1999. Nutritional management of diabetes mellitus. In: Modern Nutrition in Health and Disease. eds. Shils ME, Olson JA, Shike M and Ross AC, Lippincott Williams & Wilkins, Philadelphia, PA, pp. 1365–1394.
Chicco A, D’Alessandro ME, Karabatas L,
Gutman R, Lombardo YB. 1996. Effect of moderate levels of dietary fish
oil on insulin secretion and sensitivity, and pancreas insulin content
in normal rats. Ann Nutr Metab 40:61–70.
Fasching P, Ratheiser K, Waldhäusl W, Rohac
M, Osterrode W, Nowotny P, Vierhapper H. 1991. Metabolic effects of
fish-oil supplementation in patients with impaired glucose tolerance.
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Goh Y, Jumpsen J, Ryan E, Clandinin M:
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lipoprotein fatty acid content in NIDDM patents. Diabetologia 40:
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Hu FB, van Dam RM, Liu S. 2001. Diet and risk of type II diabetes: The role of types of fat and carbohydrate.
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Luo J, Rizkalla SW, Boillot J, Alamowitch C, Chaib
H, Bruzzo F, Desplanque N, Dalix A-M, Durand G, Slama G. 1996. Dietary
(n-3) polyunsaturated fatty acids improve adipocyte insulin action and
glucose metabolism in insulin-resistant rats: Relation to membrane
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Nobukata H, Ishikawa T, Obata M, Shibutani
Y. 2000. Long-term administration of highly purified eicosapentaenoic
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Prasad K. 2000. Oxidative stress as a
mechanismof diabetes in diabetic BB prone rats: Effects of
secoisolariciresinol diglucoside (SDG). Mol Cell Biochem 209: 89–96.
Prasad K. 2001. Secoisolariciresinol
diglucoside from flaxseed delays the development of type 2 diabetes in
Zucker rat. J Lab Clin Med 138: 32–39.
Prasad K, Mantha SV, Muir AD, Westcott
ND. 2000. Protective effect of secoisolariciresinol diglucoside against
streptozototin-induced diabetes and its mechanism.. Mol Cell Biochem
206: 141–150.
Popp-Snijders C, Schouten JA, Heine RJ, van
der Meer J, van der Veen EA. 1987. Dietary supplementation of omega-3
polyunsaturated fatty acids improves insulin sensitivity in
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Storlien LH, Kraegen EW, Chisholm DJ, Ford
GL, Bruce DG, Pascoe WS. 1987. Fish oil prevents insulin resistance
induced by high-fat feeding. Science 237:885–888.
Storlien LH, Jenkins AB, Chisholm DJ, Pascoe
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development of insulin resistance in rats. Relationship to muscle
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